Gene enrichment in maize with hypomethylated partial restriction (HMPR) libraries

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Gene enrichment in maize with hypomethylated partial restriction (HMPR) libraries.

A new technology was developed to assist gene-enrichment sequencing of any complex plant genome, employing maize as the test organism. Hypomethylated partial restriction (HMPR) libraries were constructed by using independent partial digestions with methylation-sensitive restriction enzymes HpaII (5'-CCGG-3') and HpyCH4IV (5'-ACGT-3'). Fragments of 1-4 kb were purified and cloned, followed by se...

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Approximately 80% of the maize genome comprises highly repetitive sequences interspersed with single-copy, gene-rich sequences, and standard genome sequencing strategies are not readily adaptable to this type of genome. Methodologies that enrich for genic sequences might more rapidly generate useful results from complex genomes. Equivalent numbers of clones from maize selected by techniques cal...

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ژورنال

عنوان ژورنال: Genome Research

سال: 2005

ISSN: 1088-9051

DOI: 10.1101/gr.3362105